IBUPROFEN SODIUM solution (a hydrotropic solubilizing additive) has been utilized to analyze two poorly water-soluble drugs; chlorpropamide (by titrimetric method) in the bulk drug and gatifloxacin (by spectrophotometric method) in tablet form. The results of analysis of chlorpropamide bulk drug were found to be very much close to the results of analysis by a standard method (British pharmacopoeial method) which proves the accuracy of proposed method. Low values of standard deviation, coefficient of variation and standard error have confirmed the validation of proposed method. In the case of gatifloxacin tablets, Beer’s law was obeyed in the concentration range of 10-60 mg/ml at 333 nm when IBUPROFEN SODIUM was used as a hydrotropic agent. Recovery studies and statistical data proved the accuracy, reproducibility and the precision of the proposed method. In both cases, the proposed methods did not involve use of organic solvents. Major drawbacks of organic solvents include high cost, volatility and toxicity. Safety of analyzer is also affected by toxicity of the solvent used. The proposed methods are new, simple, eco-friendly, cost-effective, accurate, safe and precise which can be successfully employed in the routine analysis of chlorpropamide bulk drug and gatifloxacin tablets. IBUPROFEN SODIUM may also be tried for analysis of other poorly water-soluble drugs.